Magnetic Resonance Imaging Predictors of Treatment Response in Late-Life Depression

This article provides a review of the current literature using structural and functional neuroimaging to identify MRI predictors of treatment response in LLD. The majority of the literature on structural MRI has focused on the vascular depression hypothesis, and studies support the view that loss of brain volume and white matter integrity was associated with poorer treatment outcomes. Studies using fMRI have reported that lower task-based activity in the prefrontal cortex and limbic regions was associated with poorer outcome. These imaging markers may be integrated into clinical decision making to attain better treatment outcomes in the future.

Source: Journal of Geriatric Psychiatry and Neurology - January 31, 2014 Category: Genetics & Stem Cells Authors: Aizenstein, H. J., Khalaf, A., Walker, S. E., Andreescu, C. Tags: Original Articles Source Type: research