Hyperhaemolysis in Patients with Haemoglobinopathies: A Single Centre Experience and Review of the Literature

Hyperhaemolysis is a severe and potentially life-threatening complication of transfusion described in numerous case reports and gaining recognition since 2009 via the UK SHOT (Serious Hazards of Transfusion) scheme. Whilst it is predominantly seen in patients with sickle cell disease there are several reports of this complication in patients with other haemoglobinopathies as well as patients with a range of other haematological diagnoses who have blood transfusions as part of their management. Our understanding of the underlying pathophysiology of this subtype of delayed transfusion reaction has increased over the last few years; however, there are still questions, which remain unanswered.
Source: Transfusion Medicine Reviews - Category: Hematology Authors: Source Type: research