Antileishmanial Effect of 5,3'-Hydroxy-7,4'-dimethoxyflavanone of Picramnia gracilis Tul. (Picramniaceae) Fruit: In Vitro and In Vivo Studies.

In conclusion, this is the first report about isolation of 5,3'-hydroxy-7,4'-dimethoxyflavanone of P. gracilis Tul. The leishmanicidal activity attributed to this flavanone is also reported for the first time. Finally, the in vitro and in vivo leishmanicidal activity reported here for 5,3'-hydroxy-7,4'-dimethoxyflavanone offers a greater prospect towards antileishmanial drug discovery and development. PMID: 26064104 [PubMed]

http://www.ncbi.nlm.nih.gov/pubmed/26064104?dopt=Abstract

Source: Advances in Pharmacological Sciences - June 14, 2015 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research