Screening for MAPK Modulators Using an In-Cell Western Assay

Several essential cellular functions are critically influenced by the Ras-Raf-MEK-ERK cascade, and pathological problems have been implicated with loss as well as gain of its activity. Therefore, there is a great demand for chemical probes that act as modulators of the cascade in order to correct medical problems associated with its malfunctions.

Source: Springer protocols feed by Cell Biology - January 29, 2014 Category: Cytology Source Type: news