Tolerance to the antinociceptive effects of chronic morphine requires c-Jun N-terminal kinase

Conclusions: These results demonstrate that JNK signaling plays a crucial role in mediating antinociception as well as chronic tolerance to the antinociceptive effects of morphine in acute, inflammatory, and neuropathic pain states. Thus, inhibition of JNK signaling pathway, via SP600125, represents an efficacious pharmacological approach to delay tolerance to the antinociceptive effects of chronic morphine in diverse pain models.
Source: Molecular Pain - Category: Molecular Biology Authors: Source Type: research