Effect of Primary Letrozole Treatment on Tumor Expression of mTOR and HIF-1{alpha} and Relation to Clinical Response

Conclusions:
In this neoadjuvant population, LET was able to modulate the phospho-mTOR and HIF-1α pathways and may define a subpopulation of nonresponders who may be most likely to benefit from mTOR inhibitors.

Source: JNCI Monographs - June 10, 2015 Category: Cancer & Oncology Authors: Generali, D., Berruti, A., Cappelletti, M. R., Zanotti, L., Brugnoli, G., Forti, M., Bedussi, F., Vailati, M. E., Milani, M., Strina, C., Ardine, M., Aguggini, S., Allevi, G., Ferrero, G., Bertoni, R., Bottini, A., Harris, A. L., Fox, S. B. Tags: Article Source Type: research