Duration of fasting but not diurnal variation affects the response to glucagon in healthy cats

The role of glucagon disturbances in diabetes is increasingly recognized. Glucagon stimulation tests (GST) have been described in cats previously but information is lacking on the response of cats to glucagon under specific conditions. The aim of this study was to assess a novel protocol for GST using human-recombinant glucagon and the effect of diurnal variation and duration of fasting using this protocol in healthy cats. All intravenous doses resulted in occasional vomiting and nausea and eventually a 20 μg/kg IM dose was chosen.
Source: Domestic Animal Endocrinology - Category: Endocrinology Authors: Source Type: research