Interleukin-6 inhibits adrenal androgen release from bovine adrenal zona reticularis cells by inhibiting the expression of steroidogenic proteins

In this study, the effects of IL-6 on adrenal androgen release were investigated. The zona reticularis (ZR) was generally isolated from bovine adrenal glands by dissection. In select experiments, the intact adrenal cortex (i.e. all three adrenocortical zones) was dissected from the adrenal glands. For androgen release experiments, ZR and intact adrenocortical cubes were dispersed into isolated cells, the cells cultured and exposed to IL-6 and/or adrenocorticotrophic hormone (ACTH), and androgen release determined by radioimmunoassay.

Source: Domestic Animal Endocrinology - June 8, 2015 Category: Endocrinology Authors: S. McIlmoil, G.B. Call, M. Barney, J. Stickland, A.M. Judd Source Type: research