Frequent expression of PD-L1 on circulating breast cancer cells

Immune checkpoint regulators such as PD-L1 have become exciting new therapeutic targets leading to long lasting remissions in patients with advanced malignancies. However, in view of the remarkable costs and the toxicity profiles of these therapies, predictive biomarkers able to discriminate responders from non-responders are urgently needed. In the present paper, we provide evidence that PD-L1 is frequently expressed on metastatic cells circulating in the blood of hormone receptor-positive, HER2-negative breast cancer patients.

Source: Molecular Oncology - June 8, 2015 Category: Cancer & Oncology Authors: Martine Mazel, William Jacot, Klaus Pantel, Kai Bartkowiak, Delphine Topart, Laure Cayrefourcq, Delphine Rossille, Thierry Maudelonde, Thierry Fest, Catherine Alix-Panabières Source Type: research