Seeing beyond the tip of the iceberg: a deep analysis of the venome of the Brazilian Rattlesnake, Crotalus durissus terrificus.

Publication date: Available online 6 June 2015 Source:EuPA Open Proteomics Author(s): Rafael D. Melani , Gabriel D.T. Araujo , Paulo C. Carvalho , Livia Goto , Fábio C.S. Nogueira , Magno Junqueira , Gilberto B. Domont The complete characterization of the snake venom protein components is a requirement for a systems-wide understanding of their biological context. In this work, we provide a deep proteomic characterization of Crotalus durissus terrificus venom using different bottom-up approaches. We identified more than five times more protein families than the sum of all identifications previously reported. For the first time in this sub-species, we report the identification of three new toxin families: CRISP, phospholipase-B, and SVVEGF. This work also describes proteins involved in regulation of toxin synthesis and processing that are present in venom. Graphical abstract

Source: EuPA Open Proteomics - June 6, 2015 Category: Bioinformatics Source Type: research