Transnasal administration of a combination of dexmedetomidine, midazolam and butorphanol produces deep sedation in New Zealand White rabbits
Conclusion and clinical relevanceThe TN route is a reliable and effective means for administration of DEX, MID and BUT to rabbits. The overall profound sedative effects and analgesic proprieties of the DMB combination can be selectively reversed depending on the needs of the procedure. Oxygen supplementation and careful monitoring are mandatory even in healthy subjects. The DMB protocol should be cautiously used in rabbits with cardiovascular or respiratory deficiencies.
Source: Veterinary Anaesthesia and Analgesia - Category: Veterinary Research Authors: Bruna Santangelo, Fabiana Micieli, Tiziana Mozzillo, Fabiana Reynaud, Francesco Marino, Luigi Auletta, Giancarlo Vesce Tags: Short Communication Source Type: research
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