Efficacy and Safety of Ferric Chloride in Controlling Hepatic Bleeding; An Animal Model Study

Conclusions: Ferric chloride is an effective haemostatic agent in controlling liver parenchymal tissue hemorrhage in an animal model.,Results: The hemostasis time of ferric chloride concentration groups was significantly less than that of the control group (P value < 0.001). The pathologic examination showed the highest frequency of low grade inflammation based on the defined pathological grading.,Materials and Methods: In this animal model study 60 male Wistar rats were used. An incision, two centimeters (cm) long and half a cm deep, was made on each rat’s liver and the hemostasis time was measured once using ferric chloride with different concentrations (5%, 10%, 15%, 25% and 50%) and then using the control method (i.e. controlling bleeding by suturing). The liver tissue was examined for pathological changes.,Objectives: This study attempts to determine the haemostatic effect of ferric chloride and compare it with that of the standard method (suturing technique) in controlling bleeding from liver parenchymal tissue.,Background: Controlling parenchymal hemorrhage especially in liver parenchyma, despite all the progress in surgical science, is still one of the challenges surgeons face saving patients’ lives and there is a research challenge among researchers in this field to introduce a more effective method.

Source: Hepatitis Monthly - June 8, 2014 Category: Infectious Diseases Source Type: research