Review of patents on microneedles application devices allowing fluid injections through the skin.

Review of patents on microneedles application devices allowing fluid injections through the skin. Recent Pat Drug Deliv Formul. 2015 Mar 13; Authors: Lhernould MS, Tailler S, Deleers M, Delchambre A Abstract Microneedles have been developed in the past few years as a new transdermal drug delivery mean. They indeed present many advantages compared to injections using hypodermic needles (reduced contaminations and epidermic reactions risks), but mostly bring comfort and compliance to patients. Microneedles may be plain and open pathways for medications though the skin, dissolving into it, or hollow and allow fluid to actually enter the dermis or the hypodermis. This review focuses on this last type of microneedles and their problematic in terms of application, which are of two types: first insure correct insertion into the skin (controlled and repeatable insertion depth mainly), second insure correct fluid delivery to the dermis (controlled infusion rate). This paper thus focuses on recently published patents about hollow microneedle applicators, i.e. microneedles applicators that allow fluid delivery to the skin. A description of several most relevant patents concerning the technology is given. The benefits and drawbacks of the different solutions are also described. PMID: 25770583 [PubMed - as supplied by publisher]
Source: Recent Patents on Drug Delivery and Formulation - Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research