Development of Drug Delivery Systems and Quality by Design.

Development of Drug Delivery Systems and Quality by Design. Recent Pat Drug Deliv Formul. 2015 Apr 24; Authors: Bruschi ML Abstract The concept and technology of drug delivery systems improved during the last sixty years. The controlled drug delivery field has its origin in the 1960s to 1980s, when a high number of systems and devices were developed to be administered by different routes and for numerous purposes. Active agents of natural and synthetic origin have been carried in each more specialized formulation with the aim to control the delivery, reduce the adverse effects, increasing the safety and patient compliance, and improving the therapeutic. Solid, semisolid and liquid systems have been developed using different strategies to modify and or control the drug release. Nowadays, from the imagined concept of the "Magic Bullet", the nanoscopic era of targeted nano-carriers has become a reality as the emergence with the development of important technologies such as the active targeting to specific cells by conjugated ligands to the system, or passive targeting to solid tumors via the EPR effect, and the PEGylation [1]. This important development in drug delivery systems has originated a high number of patent deposits and patent acquirements, and the perspective is an expressive increasing for the next decades. In this sense, it is very important to think about the pharmaceutical quality of the development process of drug deliver...
Source: Recent Patents on Drug Delivery and Formulation - Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research