Absence of anaplastic lymphoma kinase translocations in signet ring cell carcinomas of the upper gastrointestinal tract.

CONCLUSIONS: These data indicate that, despite histologic similarities between SRCC of the upper GI tract and ALK-positive NSCLC, ALK translocations are unlikely to be a significant contributor to the molecular etiology of SRCC. Further genomic investigations are ongoing. PMID: 24799969 [PubMed]

http://www.ncbi.nlm.nih.gov/pubmed/24799969?dopt=Abstract

Source: Gastrointestinal Cancer Research - June 4, 2015 Category: Cancer & Oncology Tags: Gastrointest Cancer Res Source Type: research