An assessment of risk factors associated with ifosfamide-induced encephalopathy in a large academic cancer center

Conclusions
This is the first study to demonstrate that patients with sarcoma experienced ifosfamide-induced encephalopathy more often than those with lymphoma. For all patients, predisposing factors for ifosfamide-induced encephalopathy included previous cisplatin exposure, concomitant opioids and CYP2B6 inhibitors. Laboratory values that increased ifosfamide-induced encephalopathy risk included low serum albumin, increased serum creatinine, and increased hemoglobin.

Source: Journal of Oncology Pharmacy Practice - May 5, 2015 Category: Cancer & Oncology Authors: Szabatura, A. H., Cirrone, F., Harris, C., McDonnell, A. M., Feng, Y., Voit, D., Neuberg, D., Butrynski, J., Fisher, D. C. Tags: Original Articles Source Type: research