Relationship between expression of matrix metalloproteinase-9 and adenylyl cyclase-associated protein 1 in chronic obstructive pulmonary disease

Conclusions
This study demonstrated an inverse relationship between CAP1 and MMP-9 expression, and high expression of MMP-9 and low expression of CAP1 in those with COPD compared with the non-COPD group. Overexpression of MMP-9 in lung tissue and its interaction with CAP1 is likely to play a major role in airway obstruction in COPD.

Source: Journal of International Medical Research - November 11, 2014 Category: Research Authors: Xie, S.-S., Hu, F., Tan, M., Duan, Y.-X., Song, X.-L., Wang, C.-H. Tags: Research Reports Source Type: research