The effect of MRI contrast agents on hepatic and splenic uptake in the rabbit during 99mTc‐MDP bone scintigraphy

The objective of this study was to investigate the effects of Omniscan® and Magnevist® on 99mTc‐MDP uptake in rabbits during 99mTc‐MDP bone scintigraphy. In Experiment Group 1, 30 healthy adult rabbits were randomized into six subgroups (n = 5); each subgroup experienced a different time interval between injections (30 min, 60 min, 120 min, 240 min, 360 min, 24 h). All six subgroups were injected first with Omniscan®, then with 99mTc‐MDP. After 7 days, the same six subgroups were injected with normal saline followed by 99mTc‐MDP at the same time intervals. In Experiment Group 2, 20 healthy adult rabbits were allocated randomly to four subgroups (n = 5); each subgroup experienced a different time interval between injections (30 min, 60 min, 120 min, 240 min). All four subgroups were injected first with Magnevist®, then with 99mTc‐MDP. After 7 days, the same four subgroups were injected with normal saline followed by 99mTc‐MDP. In all experiments, whole‐body skeletal imaging was performed. Liver, spleen, and background were delineated to determine the target‐to‐background (T/B) ratio. Diffusely increased intake of the imaging agent was seen in the liver and spleen when the injection‐time interval between Omniscan® and 99mTc‐MDP varied from 30 min to 240 min and when the time interval between Magnevist® and 99mTc‐MDP was 30 min–60 min. The imaging findings are consistent with the results of L/B and S/B ratios in eac...

Source: Contrast Media and Molecular Imaging - March 1, 2015 Category: Radiology Authors: Lin Qiu, Yuhui Tang, Yue Chen, Zhanwen Huang, Yan Zhu, Li Zhang, Liang Cai, Qiang Wan, Yue Feng Tags: Full Paper Source Type: research