Episode #9: TPR Podcast on hemodialysis in poisonings

Episode 9: EXTRIP Review   Written by Theresa Kim, MD   Outline EXTRIP Guideline Methodology Methanol Theophylline Lithium Acetaminophen   EXTRIP Guideline Methodology Extracorporeal treatments (ie. hemodialysis, hemoperfusion) are commonly used in poisonings despite lack of formal human trials Goal of the EXTRIP workgroup was to form an international collaboration among experts from nephrology, toxicology, critical care, pharmacology, and over 30 professional societies to form consensus recommendations and suggestions based on available research and expert opinion Clinical evidence ranked using GRADE system A-D A = high quality evidence D = very poor quality evidence Strength of consensus recommendations ranked on a 3 level scale: Level 1: strong recommendation agreed upon by large majority of experts Level 2: weak recommendation considered appropriate by majority of experts but with some disagreement Level 3: neutral position considered appropriate in right context   NOTE: The following are summaries of the key points from the ExTRIP publications. For a more complete discussion of the group’s full recommendations and suggestions, follow links from the ExTRIP website.   Methanol ECTR recommended in the following circumstances Severe methanol poisoning (coma, seizure, vision deficits, metabolic acidosis pH<7.15, persistent acidosis, AND/OR anion gap > 24 mmol/L (1D) Serum methanol concentrations >70mg/dL in context of fomepizole therapy...
Source: The Poison Review - Category: Toxicology Authors: Tags: Podcast Source Type: news