Immunological Basis of Food Allergy (IgE-Mediated, Non-IgE-Mediated, and Tolerance).

Immunological Basis of Food Allergy (IgE-Mediated, Non-IgE-Mediated, and Tolerance). Chem Immunol Allergy. 2015;101:8-17 Authors: Kim EH, Burks W Abstract Food allergy includes a number of diseases that present with adverse immunological reactions to foods and can be IgE-mediated, non-IgE-mediated, or a combination of both mechanisms. IgE-mediated food allergy involves immediate hypersensitivity through the action of mast cells, whereas non-IgE-mediated food allergy is most commonly cell-mediated. These food allergies are thought to occur as a result of a breakdown in oral tolerance and, more specifically, from an aberrant regulatory T-cell response. Ongoing studies of experimental treatments for food allergy strive to induce oral tolerance and to teach us more about the pathogenesis of food allergy. © 2015 S. Karger AG, Basel. PMID: 26022860 [PubMed - in process]
Source: Chemical Immunology and Allergy - Category: Allergy & Immunology Tags: Chem Immunol Allergy Source Type: research