Serial expression analysis of breast tumors during neoadjuvant chemotherapy reveals changes in cell cycle and immune pathways associated with recurrence and response

Conclusions: Serial gene expression analysis revealed candidate immune and proliferation pathways associated with response and recurrence. Larger studies incorporating the approach described here are warranted to identify predictive and prognostic biomarkers in the NAC setting for specific targeted therapies.Clinical trial registrationThe I-SPY 1 TRIAL was registered on April 9, 2002 as NCT00033397.
Source: Breast Cancer Research - Category: Cancer & Oncology Authors: Source Type: research