Tuning noise in gene expression

The relative contribution of promoter architecture and the associated chromatin environment in regulating gene expression noise has remained elusive. In their recent work, Arkin, Schaffer and colleagues (Dey et al, 2015) show that mean expression and noise for a given promoter at different genomic loci are uncorrelated and influenced by the local chromatin environment.

Source: Molecular Systems Biology - May 5, 2015 Category: Molecular Biology Authors: Tyagi, S. Tags: Chromatin, Epigenetics, Genomics & Functional Genomics, Quantitative Biology & Dynamical Systems, Transcription News [amp ] Views Source Type: research