Evaluation of biomarkers of oxidant–antioxidant balance in patients with acne vulgaris

This study was conducted on 40 acne vulgaris patients and 36 age-matched and sex-matched healthy controls. Patients were classified into mild, moderate, severe, and very severe on the basis of the Global Acne Grading System. Venous blood samples taken from both patients and controls were analyzed to determine the activity of the antioxidant enzymes: superoxide dismutase (SOD), catalase (CAT), and glucose-6-phosphate dehydrogenase (G6PD); the levels of malondialdehyde (MDA), a major by-product and an important marker of lipid peroxidation, were also determined. Different laboratory techniques suitable for each marker were used and the results were read spectrophotometrically. Results: A highly significant decrease in the mean blood G6PD, CAT, and SOD enzyme activities (P
Source: Journal of the Egyptian Women’s Dermatologic Society - Category: Dermatology Tags: Original articles Source Type: research