Pathway-centric analysis of the DNA damage response to chemotherapeutic agents in two breast cell lines

We present data from both a shotgun and a targeted, pathway-centric approach to highlight the different DNA repair pathway modulation in the cell lines and the correlation with viability and DNA damage assays. This type of focussed profiling may be of utility in rapidly defining non-responders undergoing systemic neoadjuvant therapy. Graphical abstract
Source: EuPA Open Proteomics - Category: Bioinformatics Source Type: research