Variation of histopathology between liver lobes

Liver biopsy is often essential in the diagnosis and management of canine liver disease. To accurately diagnose diffuse liver disease, a biopsy specimen must reliably represent the abnormalities elsewhere in the hepatic parenchyma. In several species, important lesions are distributed throughout the liver in consistent relationship with hepatic architecture. Whereas a good-quality biopsy would be expected to reveal most of these lesions, biopsy collects only a small portion of tissue, and error associated with nonhomogenous distribution of disease is possible.
Source: Advances in Small Animal Medicine and Surgery - Category: Veterinary Research Tags: Gastroenterology Source Type: research