Tissue-Specific Sparse Deconvolution for Brain CT Perfusion

Cerebral computed tomography perfusion (CTP) imaging has been advocated to detect and characterize the ischemic penumbra, and assess blood-brain barrier permeability with acute stroke or chronic cerebrovascular disease. In cerebral studies, perfusion hymodynamic parameters such as cerebral blood flow (CBF), cerebral blood volume (CBV) and mean transit time (MTT) can be computed from the time sequence of enhanced CT images to provide important guidance to clinicians. However, the associated excessive radiation exposure in the repeated scan during CTP examination is raising a great concern due to numerous recent reports from patients on over-dosage leading to biological effects including hair loss, skin burn and increased cancer risk.
Source: Computerized Medical Imaging and Graphics - Category: Radiology Authors: Source Type: research