Efficacité d’un dispositif médical à base d’acide hyaluronique liposomé contre la sécheresse vulvo-vaginale

Conclusion L’AH incorporé dans des liposomes diminue significativement les symptômes et les signes cliniques de la SVV à tous les âges et représente une alternative efficace et sûre au traitement hormonal local et/ou général après la ménopause. Objectives Hyaluronic acid (HA) is present in the vulval and vaginal conjonctive tissue. It possesses hydrating and healing properties and is indicated to treat menopause induced vulvo-vaginal atrophy. The goal of this study is to evaluate the efficacy of a medical device containing liposomal HA upon patients of different ages suffering from vulvo-vaginal dryness (VVD). Methods Tested product Mucogyne® was applied 3 times a week for 84 days by 47 patients, 28 premenopausal young women (mean age: 32 years old) and 19 post-menopausal women (mean age: 57.5 years old) all suffering from VVD associated to spontaneous pain and dyspareunia. Clinical evaluations and Vaginal Health Index (VHS) were calculated at 0, 1 and 3 months. Results A significant clinical improvement (P <0.001) occurred at 1 month (−25 % for dryness and −46 % for pain) and at 3 months (respectively −86 and −79 %). VHS was significantly improved (P <0.001) from 30 % at 1 month to 72 % after 3 months. Conclusion Liposomal AH significantly decreases symptoms and clinical signs of VVD at all ages and represents a safe and efficient alternative to topical and/or systemic hormonal therapy after menopause.
Source: Gynecologie Obstetrique and Fertilite - Category: OBGYN Source Type: research