Short‐Term Immunogenicity and Safety of an Accelerated Pre‐Exposure Prophylaxis Regimen With Japanese Encephalitis Vaccine in Combination With a Rabies Vaccine: A Phase III, Multicenter, Observer‐Blind Study

ConclusionsThis was the first randomized, controlled trial that demonstrated the strong short‐term immunogenicity of a new, accelerated, 1‐week JE‐regimen, which was noninferior to that of the standard regimen, with a satisfactory tolerability and safety profile and no impact of concomitant rabies vaccination. This accelerated regimen, if licensed, could potentially be a valid alternative for individuals requiring a primary series of JE vaccination and rabies pre‐exposure prophylaxis on short notice.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1111%2Fjtm.12210

Source: Journal of Travel Medicine - May 22, 2015 Category: Infectious Diseases Authors: Tomas Jelinek, Gerd D. Burchard, Sebastian Dieckmann, Silja Bühler, Maria Paulke‐Korinek, Hans D. Nothdurft, Emil Reisinger, Khaleel Ahmed, Dietrich Bosse, Seetha Meyer, Marco Costantini, Michele Pellegrini Tags: ORIGINAL ARTICLE Source Type: research