Acquisition of epithelial-mesenchymal transition phenotype in the tamoxifen-resistant breast cancer cell: a new role for GPER in mediating tamoxifen resistance through CAF-derived fibronectin and β1-integrin signaling pathway in tumor cells

Conclusions:
GPER/EGFR/ERK signaling upregulates β1-integrin expression and activates downstream kinases, which contributes to CAF-induced cell migration and EMT, in MCF-7R cells. GPER probably contributes to tamoxifen resistance via interaction with the tumor microenvironment in a β1-integrin dependent pattern. Thus, β1-integrin may be a potential target to improve anti-hormone therapy responses in breast cancer patients.

Source: Breast Cancer Research - May 21, 2015 Category: Cancer & Oncology Authors: Jie YuanManran LiuLi YangGang TuQing ZhuMaoshan ChenHong ChengHaojun LuoWeijie FuZhenhua LiGuanglun Yang Source Type: research