IL-15 is required for immunosurveillance and immunoprevention of HER2/neu-driven mammary carcinogenesis

Conclusions:
We demonstrated that IL-15 has a role in mammary cancer immunosurveillance and that IL-15-regulated NK and CD8+ memory cells play a role in long-lasting immunoprevention, further supporting the potential use of IL-15 as adjuvant in immunological strategies against tumors.

Source: Breast Cancer Research - May 22, 2015 Category: Cancer & Oncology Authors: Stefania CrociPatrizia NanniArianna PalladiniGiordano NicolettiValentina GrossoGiorgia BenegiamoLorena LanduzziAlessia LamolinaraMarianna IanzanoDario RanieriMassimiliano Dall¿OraManuela IezziCarla De GiovanniPier-Luigi Lollini Source Type: research