Upregulation of T-type Ca2+ channels in long-term diabetes determines increased excitability of a specific type of capsaicin-insensitive DRG neurons

Conclusions:
Capsaicin-insensitive low-pH-sensitive type of DRG neurons shows diabetes-induced upregulation of Cav3.2 subtype of T-type channels. This upregulation results in the increased excitability of these neurons and may contribute to nonthermal nociception at a later-stage diabetes.

Source: Molecular Pain - May 20, 2015 Category: Molecular Biology Authors: Dmytro DuzhyyViacheslav Viatchenko-KarpinskiEugen KhomulaNana VoitenkoPavel Belan Source Type: research