PTEN loss is a context-dependent outcome determinant in obese and non-obese endometrioid endometrial cancer patients

Endometrial cancer incidence is increasing, due in part to a strong association with obesity. Mutations in the phosphatidylinositol 3-kinase (PI3K) pathway, the central relay pathway of insulin signals, occur in the majority of endometrioid adenocarcinomas, the most common form of endometrial cancer. We sought to determine the impact of PI3K pathway alterations on progression free survival in a cohort of endometrioid endometrial cancers. Prognostic utility of PIK3CA, PIK3R1, and PTEN mutations, as well as PTEN protein loss by immunohistochemistry, was explored in the context of patient body mass index.

Source: Molecular Oncology - May 16, 2015 Category: Cancer & Oncology Authors: Shannon N. Westin, Zhenlin Ju, Russell R. Broaddus, Camilla Krakstad, Jane Li, Navdeep Pal, Karen H. Lu, Robert L. Coleman, Bryan T. Hennessy, Samuel J. Klempner, Henrica M.J. Werner, Helga B. Salvesen, Lewis C. Cantley, Gordon B. Mills, Andrea P. Myers Source Type: research