An Integrated Genomic Analysis of Papillary Renal Cell Carcinoma Type 1 Uncovers the Role of Focal Adhesion and Extracellular Matrix Pathways

Papillary renal cell carcinoma (pRCC) is the second most common RCC subtype and can be further classified as type 1 (pRCC1) or 2 (pRCC2). There is currently minimal understanding of pRCC1 pathogenesis, and treatment decisions are mostly empirical. The aim of this study was to identify biological pathways that are involved in pRCC1 pathogenesis using an integrated genomic approach. By microarray analysis, we identified a number of significantly dysregulated genes and microRNAs (miRNAs) that were unique to pRCC1.

Source: Molecular Oncology - May 13, 2015 Category: Cancer & Oncology Authors: Samantha Jane Wala, Jason Raj Karamchandani, Rola Saleeb, Andrew Evans, Qiang Ding, Rania Ibrahim, Michael Jewett, Maria Pasic, Antonio Finelli, Kenneth Pace, Evi Lianidou, George Makram Yousef Source Type: research