Efficient treatment of breast cancer xenografts with multifunctionalized iron oxide nanoparticles combining magnetic hyperthermia and anti-cancer drug delivery

Conclusion:
The therapeutic effects of breast cancer magnetic hyperthermia could be strongly enhanced by the combination of MF66 functionalized with N6L and DOX and magnetic hyperthermia. Our approach combines two ways of tumor cell killing (magnetic hyperthermia and chemotherapy) and represents a straightforward strategy for translation into the clinical practice when injecting nanoparticles intratumorally.

Source: Breast Cancer Research - May 13, 2015 Category: Cancer & Oncology Authors: Susanne KossatzJulia GrandkePierre CouleaudAlfonso LatorreAntonio AiresKieran Crosbie-StauntonRobert LudwigHeidi DähringVolker EtteltAna Lazaro-CarrilloMacarena CaleroMaha SaderJosé CourtyYuri VolkovAdriele Prina-MelloAngeles VillanuevaÁlvaro SomozaAit Source Type: research