The inducible E3 ubiquitin ligases SIAH1 and SIAH2 perform critical roles in breast and prostate cancers

In order to grow and survive, cells have to prevent an excessive accumulation of proteins as well as an unbalanced degradation of proteins [1,2]. The posttranslational modification of proteins, with poly-ubiquitin chains linked via lysine-48 of ubiquitin moieties, promotes their intracellular degradation by a multi-protease complex termed the proteasome [1,3,4]. The precise control of this ubiquitin-proteasome system (UPS) ensures that damaged, unnecessary, misfolded, and potentially harmful proteins are removed.
Source: Cytokine and Growth Factor Reviews - Category: Molecular Biology Authors: Tags: Mini review Source Type: research