Effect of low doses of methamphetamine on rat limbic‐related neurotensin systems

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GRAPHICAL ABSTRACT
Our findings suggest that 4 low doses of METH (∼0.25 mg/kg) have opposite effects on limbic‐related neurotensin systems than high doses (∼5‐10 mg/kg). Thus, low‐dose METH increases NT release by activating a combination of D1/D2 receptors while high‐dose METH reduces NT release by selectively activating D1 receptors.

Source: Synapse - May 13, 2015 Category: Neurology Authors: Mario E. Alburges, Amanda J. Hoonakker, Nathaniel M. Cordova, Christina M. Robson, Lisa M. McFadden, Amber L. Martin, Glen R. Hanson Tags: Research Article Source Type: research