Paroxysmal nocturnal hemoglobinuria clone in 103 Brazilian patients: diagnosis and classification

Conclusion: This retrospective review of 103 patients over an 11-year period represents the largest collection of paroxysmal nocturnal hemoglobinuria cases from a single center in Brazil. Flow cytometry showed that a larger clone was associated with classical symptoms and increased risk of thrombosis, even in patients with bone marrow failure, whereas a smaller clone was associated with bone marrow aplasia.
Source: Revista Brasileira de Hematologia e Hemoterapia - Category: Hematology Source Type: research