CCR9-mediated Signaling through β-catenin and Identification of a Novel CCR9 Antagonist

In this study, we characterized a novel CCR9-mediated pathway that promotes pancreatic cancer cell invasion and drug resistance, indicating that CCR9 may play a critical role in cancer progression through activation of β-catenin. We noted that the CCL25/CCR9 axis in pancreatic cancer cells induced the activation of β-catenin, which enhanced cell proliferation, invasion, and drug resistance.

Source: Molecular Oncology - May 11, 2015 Category: Cancer & Oncology Authors: Sangjun Lee, Eileen L. Heinrich, Lily Li, Jianming Lu, Audrey H. Choi, Rachel A. Levy, Jeffrey E. Wagner, M.L. Richard Yip, Nagarajan Vaidehi, Joseph Kim Source Type: research