Chronic Social Isolation During Adolescence Augments Catecholamine Response to Acute Ethanol in the Basolateral Amygdala

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GRAPHICAL ABSTRACT TEXT
Adolescent social isolation resulted in decreased extracellular DA and an augmented dopaminergic and noradrenergic response to acute ethanol.  These changes may promote increased BLA excitability and a strengthening of the BLA‐NAc glutamatergic projection, alterations that could contribute to the elevated ethanol intake observed in rats subjected to chronic early‐life stress.

Source: Synapse - May 12, 2015 Category: Neurology Authors: Anushree N. Karkhanis, Nancy J. Alexander, Brian A. McCool, Jeffrey L. Weiner, Sara R. Jones Tags: Research Article Source Type: research