Sodium channel NaV1.7 in vascular myocytes, endothelium, and innervating axons in human skin
Conclusions:
These observations suggest that the activity of mutant Nav1.7 channels in smooth muscle cells of skin vasculature and innervating sensory and sympathetic fibers contribute to the skin reddening and/or pain in IEM and PEPD.
Source: Molecular Pain - Category: Molecular Biology Authors: Frank RicePhillip AlbrechtJames WymerJoel BlackIngemar MerkiesCatharina FaberStephen Waxman Source Type: research
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