Antimetastatic Effects of Gambogic Acid are Mediated via the Actin Cytoskeleton and NF‐κB Pathways in SK‐HEP1 Cells

In this study, the influence of GA on migration and invasion of SK‐HEP1 cells was evaluated. At concentrations above 0.6 μM, GA reduced cell proliferation in SK‐HEP1 cells without affecting proliferation of noncancerous HEK‐293 cells. GA also suppressed migration and invasion of SK‐HEP1 cells. GA downregulated the expression of the integrin β1/rho family GTPase signaling pathway, suppressed the actin rearrangement related to cell cytoskeleton and migration and decreased matrix metalloproteinases MMP‐2, MMP‐9, and NF‐κB expression involved in cancer invasion. These results suggest that GA may be a potential lead in developing an antimetastatic therapeutic for the treatment of HCC. © 2015 Wiley Periodicals, Inc.

Source: Drug Development Research - March 1, 2015 Category: Drugs & Pharmacology Authors: Min‐Seok Park, Nan‐Hee Kim, Chang‐Won Kang, Chul‐Woong Oh, Gun‐Do Kim Tags: Research Article Source Type: research