Pharmacokinetics and Pharmacodynamics of Immunosuppressive Drugs in Elderly Kidney Transplant Recipients

Elderly patients are a fast growing population among transplant recipients over the past decades. Both the innate and adaptive immune reactivity decrease with age, which is believed to contribute to the decreased incidence of acute rejection and increased infectious death rate in elderly transplant recipients. In contrast to recipient age, donor age is associated with a higher incidence of acute rejection.Pharmacokinetic studies in renal transplant recipients show that CNI troughs are >50% higher in elderly compared to younger patients given the same dose normalized by body weight.
Source: Transplantation Reviews - Category: Transplant Surgery Authors: Source Type: research