Effects of acepromazine or dexmedetomidine on fentanyl disposition in dogs during recovery from isoflurane anesthesia

Conclusions and clinical relevanceThe dose rates of fentanyl used in this study achieved previously established analgesic plasma concentrations for the duration of the infusion. Despite alterations in fentanyl pharmacokinetics, differences in fentanyl plasma concentrations among treatments during recovery from anesthesia were small and were unlikely to be of clinical significance.

Source: Veterinary Anaesthesia and Analgesia - May 1, 2015 Category: Veterinary Research Authors: Stephanie Keating, Carolyn Kerr, Wayne McDonell, Alexander Valverde, Ron Johnson, Heather Knych, Andrea Edginton Tags: Research Paper Source Type: research