Salsolinol – a potential modulator of the activity of the hypothalamic-pituitary-adrenal axis in nursing and post-weaning sheep

The most well-known physiological action of salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline) is the stimulation of prolactin secretion, especially during lactation. Additionally, our recent work demonstrated that salsolinol inhibits the stress-induced activity of the hypothalamic-pituitary-adrenal (HPA) axis in lactating sheep. Here we investigated whether salsolinol regulates the basal activity of the HPA axis in lactating sheep and whether its inhibitory action on the stress-induced activity of the HPA axis is present during the post-weaning period.
Source: Domestic Animal Endocrinology - Category: Endocrinology Authors: Source Type: research