Mechanism of irradiation-induced mammary cancer metastasis: A role for SAP-dependent Mkl1 signaling

Radiotherapy is a standard treatment after conservative breast cancer surgery. Clinical and experimental evidence indicates that patients with local breast cancer relapse within a previously irradiated area have an increased risk of distant metastasis formation. The mechanisms responsible for the increased aggressiveness remain to be fully understood. In the present study, we used the clinically relevant 4T1 breast cancer model mimicking aggressive local relapse after radiotherapy to identify differences between tumors grown in untreated versus preirradiated mammary glands.
Source: Molecular Oncology - Category: Cancer & Oncology Authors: Source Type: research