The hunt for origins of DNA replication in multicellular eukaryotes.

The hunt for origins of DNA replication in multicellular eukaryotes. F1000Prime Rep. 2015;7:30 Authors: Urban JM, Foulk MS, Casella C, Gerbi SA Abstract Origins of DNA replication (ORIs) occur at defined regions in the genome. Although DNA sequence defines the position of ORIs in budding yeast, the factors for ORI specification remain elusive in metazoa. Several methods have been used recently to map ORIs in metazoan genomes with the hope that features for ORI specification might emerge. These methods are reviewed here with analysis of their advantages and shortcomings. The various factors that may influence ORI selection for initiation of DNA replication are discussed. PMID: 25926981 [PubMed]
Source: F1000 Medicine Reports - Category: Biomedical Science Tags: F1000Prime Rep Source Type: research