Sigma-1 receptor directly interacts with Rac1-GTPase in the brain mitochondria
Conclusion:
We suggest that Sig1R through Rac1 signaling induces mild oxidative stress that possibly is involved in the regulation of neuroplasticity, as well as in the prevention of apoptosis and autophagy.
Source: BMC Biochemistry - Category: Biochemistry Authors: Nino NatsvlishviliNino GoguadzeElene ZhuravliovaDavid Mikeladze Source Type: research