An original phylogenetic approach identified mitochondrial haplogroup T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers

Conclusions:
This study illustrates how original approaches like the phylogeny-based method we used can empower classical molecular epidemiological studies aimed at identifying association or risk modification effects.

Source: Breast Cancer Research - April 25, 2015 Category: Cancer & Oncology Authors: Sophie BleinClaire BardelVincent DanjeanLesley McGuffogSue HealeyDaniel BarrowdaleAndrew LeeJoe DennisKaroline KuchenbaeckerPenny SoucyMary TerryWendy ChungDavid GoldgarSaundra BuysRamunas JanaviciusLaima TihomirovaNadine TungCecilia DorflingElizabeth van Source Type: research