Pertinence de la procédure du ganglion sentinelle dans les cancers du sein multifocaux et multicentriques

Conclusion Malgré les biais méthodologiques des études incluses dans cette revue de la littérature, les taux de faux négatif de la procédure du ganglion sentinelle dans les cancers du sein multicentriques et multifocaux sont inférieurs à 10 % avec un faible taux de récidive axillaire. Malgré l’absence d’étude randomisée, cette procédure peut être réalisée en routine en respectant une procédure technique rigoureuse. Objectives The sentinel lymph node biopsy is a gold standard in the management of breast cancer. Its role in multifocal or multicentric tumors is still evolving. The aim of this study is to assess the feasibility and pertinence of sentinel lymph node biopsy in multifocal and multicentric tumors based on a systematic review of literature. Methods A systematic review was conducted searching in the following electronic databases PubMed using “sentinel lymph node biopsy”, “breast cancer”, “multifocal tumor”, “multicentric tumor” and “multiple tumor” as keywords. We included original articles published between 2000 and 2014, both French and English, studying feasibility of sentinel lymph node biopsy in invasive breast cancer, multicentric and/or multifocal tumors. The first end point was success rate and false negative rate. Results Twenty-six articles were included in this literature review, with 2212 cases (782 multifocal, 737 multicentric and 693 multiple tumors). Percentage of tumors whose stage was higher than stage T...
Source: Gynecologie Obstetrique and Fertilite - Category: OBGYN Source Type: research