Detection of Fetal Aneuploidy Using Cell-Free DNA: A Literature Review

Cell-free fetal DNA (cffDNA) is a highly accurate screening test for major aneuploidies. Despite high detection rates and low false-positive rates compared to current screening methods, cffDNA testing is approved for use in only the high-risk population and is expensive for low-risk women because of a lack of insurance coverage. As the technology improves and research demonstrates the efficacy of cffDNA testing in the general population, insurance coverage of this test likely will be extended to all women. At that time, cffDNA testing in most cases will replace current screening methods. Furthermore, cffDNA testing may become a routine diagnostic test, effectively rendering most invasive diagnostic procedures obsolete.

Source: Journal of Diagnostic Medical Sonography - January 23, 2014 Category: Radiology Authors: Webb, K. E. Tags: Literature Reviews Source Type: research